The pseudolymphoma syndrome that may mimic malignant lymphoma clinically and histopathologically has been described as a hypersensitivity reaction to anticonvulsant drugs. It consists of the triad of a fever, generalized rash and lymphadenopathy.
In
some cases, varying degrees of malaise, hepatosplenomegaly, abnormal liver function tests, arthralgias, eosinophilia and blood dyscriasias may also be present, We report a case of pseudolymphoma syndrome due to carbamazepine in a 47-year-old man.
He had
a diffuse edematous and erythematous patches, papules and vesicles associated with high fever, hepatosplenomegaly and lymphadenopathy.
The histopathologic finding showed a dense atypical mononuclear cell infiltrate of the upper dermis associated with Pautrier's microabscess like structures and severe dermal edema. Laboratory findings revealed leukocytosis and an abnormal liver
function
test. Three weeks after the with drawal of carbamazepine and treatment with oral prednisolone, his skin lesion and general condition markedly improved. (Kor J Dermatol 1995;33(4) : 775~779)
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